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A reignited debate over the cell(s) of origin for glioblastoma and its clinical implications

Xiaolin Fan, Yanzhen Xiong, Yuan Wang

Frontiers of Medicine 2019, Volume 13, Issue 5,   Pages 531-539 doi: 10.1007/s11684-019-0700-1

Abstract: are primary GBMs that are full-blown at diagnosis without evidences of a pre-existing less-malignant precursorNeural stem cells and oligodendrocyte precursor cells are the two major candidates for the cell(s) ofLatest data from human samples have reignited the longstanding debate over which cells are the clinically

Keywords： glioblastoma     cell(s) of origin     neural stem cells     oligodendrocyte precursor cells     subventricular zone    

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Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis

Frontiers of Medicine doi: 10.1007/s11684-023-1017-7

Abstract: conducting single-cell RNA-seq analyses on 26 gliomas, we reported their classification into primitive oligodendrocyteprecursor cell (pri-OPC)-like and radial glia (RG)-like tumors and validated it in a public cohort andSome specific genes not expressed in normal immune cells were found in glioma-infiltrating lymphocytesas validated by the increased expression of LGALS3 upon IGKC overexpression in Jurkat cells

Keywords： single-cell RNA-seq     glioma     radial glia     primitive oligodendrocyte precursor cell     immune escape    

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Early T-cell precursor leukemia: a subtype of high risk childhood acute lymphoblastic leukemia

Meilin Ma, Xiang Wang, Jingyan Tang, Huiliang Xue, Jing Chen, Ci Pan, Hua Jiang, Shuhong Shen

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 416-420 doi: 10.1007/s11684-012-0224-4

Abstract: development in recent years has found a subgroup of patients with a phenotype that resembles early T-cell precursorThis novel subtype of T-ALL was called early T-cell precursor acute lymphoblastic leukemia (ETP-ALL).Our findings demonstrate that early T-cell precursor leukemia is a very high-risk subtype of acute lymphoblastic

Keywords： acute lymphoblastic leukemia     early T precursor     prognosis    

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The role of natriuretic peptide precursor A gene polymorphism in the development of coronary heart disease

Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 437-442 doi: 10.1007/s11684-009-0074-x

Abstract: Natriuretic peptide precursor A (NPPA) is synthesized, stored, and released by atrial myocytes.

Keywords： natriuretic peptide precursor A     coronary heart disease     gene polymorphism     allelic discrimination     polymorphism    

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Carbon-coated lithium titanate: effect of carbon precursor addition processes on the electrochemical

Shilei Ding, Zelong Jiang, Jing Gu, Hongliang Zhang, Jiajia Cai, Dongdong Wang

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 1,   Pages 148-155 doi: 10.1007/s11705-020-2022-x

Abstract: composites were synthesized using the ball-milling-assisted calcination method with different carbon precursor

Keywords： lithium titanate     carbon-coated     carbon precursor     synthetic process    

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Particle formation of hydroxyapatite precursor containing two components in a spray pyrolysis process

W. Widiyastuti, Adhi Setiawan, Sugeng Winardi, Tantular Nurtono, Heru Setyawan

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 1,   Pages 104-113 doi: 10.1007/s11705-014-1406-1

Abstract: The particle formation mechanism of hydroxyapatite precursor containing two components, Ca(OOCCH ) anddroplets, a second evaporation due to crust formation, the decomposition reaction of each component of the precursor, and a solid-state reaction that included the kinetic parameters of the precursor regarding its twoThe rate of evaporation and the reacted fraction of the precursor both increased with temperature.were also suitable for predicting the average size of particles that contain two components in the precursor

Keywords： droplet     hydroxyapatite particle     CFD     tubular furnace     spray pyrolysis    

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Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia

Jianfeng Li, Yuting Dai, Liang Wu, Ming Zhang, Wen Ouyang, Jinyan Huang, Saijuan Chen

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 347-371 doi: 10.1007/s11684-020-0821-6

Abstract: B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is characterized by genetic alterations with

Keywords： BCP-ALL     subtypes     translocation     aneuploidy     sequence mutations    

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Hydrothermal synthesis of crystalline α-/β-MnO2 nanorods via γ-MnOOH nanorod precursors

ZHANG Weixin, REN Xiangbin, YANG Zeheng, WANG Hua, WANG Qiang, HUANG Fei

Frontiers of Chemical Science and Engineering 2007, Volume 1, Issue 4,   Pages 365-371 doi: 10.1007/s11705-007-0066-9

Abstract: -MnO nanorods have been successfully prepared via a facile hydrothermal method from -MnOOH nanorods precursorThe -MnO nanorods are prepared from the 100°C -MnOOH precursor, while the -MnO nanorods are obtainedfrom the 150°C -MnOOH precursor, respectively.

Keywords： obtained     -MnOOH precursor     Besides     high-resolution transmission     precursor    

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Porcine pluripotent stem cells: progress, challenges and prospects

Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 8-27 doi: 10.15302/J-FASE-2018233

Abstract:

Pluripotent stem cells (PSCs) are characterized by their capacity for high self-renewal and multipledifferentiation potential and include embryonic stem cells, embryonic germ cells and induced PSCs.

Keywords： embryonic germ cells     embryonic stem cells     induced pluripotent stem cells     pigs     pluripotent stem cells    

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Determination of telomerase activity in stem cells and non-stem cells of breast cancer

LI Zhi, HE Yanli, ZHANG Jiahua, ZHANG Jinghui, HUANG Tao

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 294-298 doi: 10.1007/s11684-007-0056-9

Abstract: Although all normal tissue cells, including stem cells, are genetically homologous, variation in geneIn normal adults, telomerase activation mainly presents in tissue stem cells and progenitor cells givingand only minorities of cells, designated as cancer stem cells, undergo processes analogous to the self-renewalcells that were phenotypically sorted by examining surface marker expression.The results indicated that cancer stem cells show a higher level of enzyme activity than non-stem cells
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Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 34-47 doi: 10.1007/s11684-017-0606-8

Abstract: and antibody-producing B cells) achieve viral clearance and host recovery.Adaptive T and B cells maintain immunological memory and provide protection against subsequent infectionsRecent studies also shed light on the role of innate T-cells (MAIT cells, gd T cells, and NKT cells)We summarize the current knowledge on influenza-specific innate MAIT and gd T cells as well as adaptiveCD8+ and CD4+ T cells, and discuss how these responses can be harnessed by novel

Keywords： influenza     innate T cells     CD4+ and CD8+ T cells     vaccination    

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Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review

Qijing LEI, Qin PAN, Shuai YU, Na LI, Shulin CHEN, Kuldip SIDHU, Jinlian HUA

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 28-32 doi: 10.15302/J-FASE-2018222

Abstract:

Primordial germ cells (PGCs) are regarded as unipotent cells that can produce only either spermatogoniaHowever, PGCs can be converted into the pluripotent state by first dedifferentiation to embryonic germ cellsand then by reprogramming to induce them to become pluripotent stem cells (iPSCs).These two stages can be completely implemented with mouse cells.

Keywords： pig     pluripotent stem cells     primordial germ cells     reprogramming    

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4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 20-25 doi: 10.1007/s11684-009-0006-9

Abstract: The function of 4-1BB/4-1BBL expressed by the immune cells has been the focus for many tumor immunotherapyIn this study, 4-1BBL was expressed in non-immune cells and non-tumor cells, and the role of 4-1BBL in-1BBL cDNA sequence was constructed, and the plasmid was transfected into baby hamster kidney (BHK) cellsand murine muscle cells by means of lipofectin-mediated or naked plasmid DNA injection into the muscleThe study demonstrated that the molecule 4-1BBL expressed by BHK cells could enhance the proliferation

Keywords： 4-1BB ligand     tumor immunotherapy     tumor microenvironment    

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The past, present and future of bovine pluripotent stem cells: a brief overview

Xiuchun TIAN

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 3-7 doi: 10.15302/J-FASE-2018247

Abstract:

Although the pursuit of bovine embryonic stem cells started more than 26 years ago for the purposeof gene-targeting, true pluripotent stem cells in this economically important species are still elusiveWith the rapid advances in genome-editing and cloning using homologously recombined somatic cells, theneed for pluripotent stem cells for precise genetic modification in any species became questionable.pluripotency circuitry across mammalian species may be the main objective for studying pluripotent stem cells

Keywords： bovine     embryonic     induced     pluripotent stem cells    

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Comparison of human nasal epithelial cells grown as explant outgrowth cultures or dissociated tissue

Jian Jiao, Na Meng, Hong Wang, Luo Zhang

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 486-491 doi: 10.1007/s11684-013-0287-x

Abstract: cell growth characteristics, ciliated cell differentiation, and function of human nasal epithelial cellsdensity appeared at 7th–10th culture day and declined with time, with the lifespan of ciliated cellsOverall, 10% of the cells in explant cultures and 20% of the cells in the dissociated tissue culturestissue culture techniques are suitable for growing well-differentiated nasal ciliated and non-ciliated cells, which have growth characteristics and ciliary activity similar to those of nasal epithelial cells 

Keywords： ciliated cells     ciliary beat frequency     dissociated tissue culture     explant culture     nasal epithelial cells    

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Title Author Date Type Operation

A reignited debate over the cell(s) of origin for glioblastoma and its clinical implications

Xiaolin Fan, Yanzhen Xiong, Yuan Wang

Journal Article

Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis

Journal Article

Early T-cell precursor leukemia: a subtype of high risk childhood acute lymphoblastic leukemia

Meilin Ma, Xiang Wang, Jingyan Tang, Huiliang Xue, Jing Chen, Ci Pan, Hua Jiang, Shuhong Shen

Journal Article

The role of natriuretic peptide precursor A gene polymorphism in the development of coronary heart disease

Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,

Journal Article

Carbon-coated lithium titanate: effect of carbon precursor addition processes on the electrochemical

Shilei Ding, Zelong Jiang, Jing Gu, Hongliang Zhang, Jiajia Cai, Dongdong Wang

Journal Article

Particle formation of hydroxyapatite precursor containing two components in a spray pyrolysis process

W. Widiyastuti, Adhi Setiawan, Sugeng Winardi, Tantular Nurtono, Heru Setyawan

Journal Article

Emerging molecular subtypes and therapeutic targets in B-cell precursor acute lymphoblastic leukemia

Jianfeng Li, Yuting Dai, Liang Wu, Ming Zhang, Wen Ouyang, Jinyan Huang, Saijuan Chen

Journal Article

Hydrothermal synthesis of crystalline α-/β-MnO2 nanorods via γ-MnOOH nanorod precursors

ZHANG Weixin, REN Xiangbin, YANG Zeheng, WANG Hua, WANG Qiang, HUANG Fei

Journal Article

Porcine pluripotent stem cells: progress, challenges and prospects

Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU

Journal Article

Determination of telomerase activity in stem cells and non-stem cells of breast cancer

LI Zhi, HE Yanli, ZHANG Jiahua, ZHANG Jinghui, HUANG Tao

Journal Article

Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Journal Article

Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review

Qijing LEI, Qin PAN, Shuai YU, Na LI, Shulin CHEN, Kuldip SIDHU, Jinlian HUA

Journal Article

4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Journal Article

The past, present and future of bovine pluripotent stem cells: a brief overview

Xiuchun TIAN

Journal Article

Comparison of human nasal epithelial cells grown as explant outgrowth cultures or dissociated tissue

Jian Jiao, Na Meng, Hong Wang, Luo Zhang

Journal Article